Yes, the plugin works on WordPress Multisite networks. There are two configuration approaches.
Per-site activation
Activate the plugin on individual sites in your network. Each site has its own linked cloud accounts, modules, and settings. Common setup for agencies hosting multiple client sites in one network.
Network-wide activation
Activate the plugin network-wide. The plugin code runs on every site in the network.
License coverage
How a Multisite network counts against your license tier depends on your activation choice and the tier you bought. If you're unsure how your Multisite setup maps to your license, see Which License do I need? or contact our support with the details of your network.